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Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation.

Authors
  • 1
Type
Published Article
Journal
Journal of proteome research
Publication Date
Volume
6
Issue
1
Pages
25–33
Identifiers
PMID: 17203945
Source
Medline

Abstract

Cold acclimation induces an adaptative increase in respiration in brown adipose tissue (BAT). A comparative analysis by two-dimensional differential in-gel electrophoresis of mitochondrial protein patterns found in rat control and cold-acclimated BAT was performed. A total of 58 proteins exhibiting significant differences in their abundance was unambiguously identified. Proteins implicated in the major catabolic pathways were up-regulated as were ATP synthase and mitofilin. Moreover, these results support the fact that adipocytes can balance their ATP synthesis and their heat production linked to UCP1-sustained uncoupling.

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