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MitoProt, a Macintosh application for studying mitochondrial proteins.

Authors
  • Claros, M G1
  • 1 Ecole Normale Supérieure, Laboratoire de Génétique Moléculaire, CNRS URA 1302, Paris, France.
Type
Published Article
Journal
Computer applications in the biosciences : CABIOS
Publication Date
August 1995
Volume
11
Issue
4
Pages
441–447
Identifiers
PMID: 8521054
Source
Medline
License
Unknown

Abstract

The paper describes the Macintosh program MitoProt, which is suitable for studying mitochondrion-related proteins. MitoProt supplies a series of parameters that permit theoretical evaluation of mitochondrial targeting sequences, as well as calculation of the most hydrophobic fragment of 17 residues in the sequence, and a new parameter called mesohydrophobicity. The last two calculations are important for predicting the putative importability of a protein into mitochondria. Taken together, targeting sequence and hydrophobicity characteristics enable one to predict whether a given protein could be mitochondrial when no previous information on the nature of the sequence is available.

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