Affordable Access

deepdyve-link
Publisher Website

Mitochondrial Transport, Partitioning and Quality Control at the Heart of Cell Proliferation and Fate Acquisition

Authors
  • Kumar Sharma, Rakesh
  • Chafik, Abderrahman
  • Bertolin, Giulia
Publication Date
Oct 18, 2021
Identifiers
DOI: 10.20944/preprints202106.0657.v1
OAI: oai:HAL:hal-03383673v1
Source
HAL-Rennes 1
Keywords
Language
English
License
Unknown
External links

Abstract

Mitochondria are essential to cell homeostasis, and alterations in mitochondrial distribution, segregation or turnover have been linked to complex pathologies such as neurodegenerative diseases or cancer. Understanding how these functions are coordinated in specific cell types is a major challenge to discover how mitochondria globally shape cell functionality. In this review, we will first describe how mitochondrial transport and dynamics are regulated throughout the cell cycle in yeast and in mammals. Second, we will explore the functional consequences of mitochondrial transport and partitioning on cell proliferation, fate acquisition, stemness, and on the way cells adapt their metabolism. Last, we will focus on how mitochondrial clearance programs represent a further layer of complexity for cell differentiation, or in the maintenance of stemness. Defining how mitochondrial transport, dynamics and clearance are mutually orchestrated in specific cell types may help our understanding of how cells can transition from a physiological to a pathological state.

Report this publication

Statistics

Seen <100 times