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Mitochondrial quality control pathways: PINK1 acts as a gatekeeper.

Authors
  • Leites, Elvira P1
  • Morais, Vanessa A2
  • 1 iMM Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal. , (Portugal)
  • 2 iMM Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal. Electronic address: [email protected] , (Portugal)
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publisher
Elsevier
Publication Date
May 27, 2018
Volume
500
Issue
1
Pages
45–50
Identifiers
DOI: 10.1016/j.bbrc.2017.06.096
PMID: 28647367
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Mitochondria have a pivotal role in the maintenance of cell homeostasis and survival. Mitochondria are involved in processes such as ATP production, reactive oxygen species production, apoptosis induction, calcium homeostasis and protein degradation. Thus, mechanisms that regulate the intrinsic quality of mitochondria have a crucial role in dictating overall cell fate. The importance of these well-regulated mechanisms is highlighted in disease scenarios such as neurodegeneration, cancer and neuromuscular atrophy. How mitochondria senses and regulates their intrinsic quality control, and consequently cell survival, is still not fully understood. In this review, we discuss the pathways that are at present considered as state-of-the-art for mitochondria quality control regulation, and highlight a mitochondrial protein-PINK1-that has revealed to act as a mitochondrial gatekeeper able to sense the presence of healthy or damaged mitochondria. Copyright © 2017. Published by Elsevier Inc.

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