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Mitochondrial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing

Authors
  • LARRY SIMPSON
  • RUSLAN APHASIZHEV
  • GUANGHAN GAO
  • XUEDONG KANG
Publisher
Copyright 2004 by RNA Society
Publication Date
Feb 01, 2004
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

A number of mitochondrial proteins have been identified in Leishmania sp. and Trypanosoma brucei that may be involved in U-insertion/deletion RNA editing. Only a few of these have yet been characterized sufficiently to be able to assign functional names for the proteins in both species, and most have been denoted by a variety of species-specific and laboratory-specific operational names, leading to a terminology confusion both within and outside of this field. In this review, we summarize the present status of our knowledge of the orthologous and unique putative editing proteins in both species and the functional motifs identified by sequence analysis and by experimentation. An online Supplemental sequence database (http://164.67.60.200/proteins/protsmini1.asp) is also provided as a research resource.

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