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Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells

Authors
  • Rasola, Andrea
  • Neckers, Len
  • Picard, Didier
Type
Published Article
Journal
Trends in Cell Biology
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Mar 17, 2014
Identifiers
DOI: 10.1016/j.tcb.2014.03.005
Source
Elsevier
Keywords
License
Unknown

Abstract

Many tumors undergo a dramatic metabolic shift known as the Warburg effect in which glucose utilization is favoured and oxidative phosphorylation is down-regulated, even when oxygen availability is plentiful. However, the mechanistic basis for this switch has remained unclear. Recently several independent groups identified TRAP1, a mitochondrial molecular chaperone of the Hsp90 family, as a key modulator of mitochondrial respiration. While all reports agree that this activity of TRAP1 has important implications for neoplastic progression, data from the different groups only partially overlap, suggesting that TRAP1 may have complex and possibly contextual effects on tumorigenesis. In the present review, we analyze these recent findings and attempt to reconcile these observations

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