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Mitochondrial impact of human immunodeficiency virus and antiretrovirals on infected pediatric patients with or without lipodystrophy.

Authors
  • Morén, Constanza
  • Noguera-Julian, Antoni
  • Rovira, Núria
  • Corrales, Ester
  • Garrabou, Glòria
  • Hernández, Sandra
  • Nicolás, Mireia
  • Tobías, Ester
  • Cardellach, Francesc
  • Miró, Oscar
  • Fortuny, Clàudia
Type
Published Article
Journal
The Pediatric Infectious Disease Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Nov 01, 2011
Volume
30
Issue
11
Pages
992–995
Identifiers
DOI: 10.1097/INF.0b013e3182253c54
PMID: 21697766
Source
Medline
License
Unknown

Abstract

We determined the mitochondrial status of a group of HIV-infected children, some with body fat abnormalities (BFA). We included 24 controls, 16 HIV-infected untreated, 26 HIV-infected treated, 6 BFA-untreated, and 21 BFA-treated patients. Genetic, translational, and functional mitochondrial values were measured. As compared with controls, mitochondrial DNA depletion and a reduction in functionality were found in BFA groups.

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