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Mitochondrial Functions in Infection and Immunity.

Authors
  • Tiku, Varnesh1
  • Tan, Man-Wah2
  • Dikic, Ivan3
  • 1 Department of Infectious Diseases, Genentech Inc, South San Francisco, USA.
  • 2 Department of Infectious Diseases, Genentech Inc, South San Francisco, USA. Electronic address: [email protected]
  • 3 Department of Infectious Diseases, Genentech Inc, South San Francisco, USA; Institute for Biochemistry II. Goethe University Clinic, Frankfurt, Germany. Electronic address: [email protected] , (Germany)
Type
Published Article
Journal
Trends in cell biology
Publication Date
Apr 01, 2020
Volume
30
Issue
4
Pages
263–275
Identifiers
DOI: 10.1016/j.tcb.2020.01.006
PMID: 32200805
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Mitochondria have a central role in regulating a range of cellular activities and host responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and functions to influence their intracellular survival or evade host immunity. On the other side, major host responses elicited against infections are directly dependent on mitochondrial functions, thus placing mitochondria centrally in maintaining homeostasis upon infection. In this review, we summarize how different bacteria and viruses impact morphological and functional changes in host mitochondria and how this manipulation can influence microbial pathogenesis as well as the host cell metabolism and immune responses. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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