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Mitochondrial free Ca2+ concentration in living cells.

Authors
  • Sheu, S S
  • Jou, M J
Type
Published Article
Journal
Journal of bioenergetics and biomembranes
Publication Date
Oct 01, 1994
Volume
26
Issue
5
Pages
487–493
Identifiers
PMID: 7896764
Source
Medline
License
Unknown

Abstract

Evidence has accrued during the past two decades that mitochondrial Ca2+ plays an important role in the regulation of numerous cell functions such as energy metabolism. This implies that mitochondrial Ca2+ transport systems might be able to relay the changes of cytosolic Ca2+ concentration ([Ca2+]c) into mitochondrial matrix for regulating biochemical activities. To substantiate this idea, measurements of intramitochondrial free Ca2+ concentration ([Ca2+]m) become essential. In this article, we review the results from recent studies attempting to measure [Ca2+]m in living cells. In addition, the significance of each study is discussed.

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