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Mitochondrial Dysfunction and Multiple Sclerosis

Authors
  • de barcelos, isabella peixoto
  • troxell, regina m.
  • graves, jennifer s.
Publication Date
May 11, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

s disease. In MS, neurological disability results from inflammation, demyelination, and ultimately, axonal damage within the central nervous system. The sustained inflammatory phase of the disease leads to ion channel changes and chronic oxidative stress. Several independent investigations have demonstrated mitochondrial respiratory chain deficiency in MS, as well as abnormalities in mitochondrial transport. These processes create an energy imbalance and contribute to a parallel process of progressive neurodegeneration and irreversible disability. The potential roles of mitochondria in neurodegeneration are reviewed. An overview of mitochondrial diseases that may overlap with MS are also discussed, as well as possible therapeutic targets for the treatment of MS and other neurodegenerative conditions.

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