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The mitochondrial DNA HVI and HVII sequences and haplogroup distribution in a population sample from Vietnam.

  • Nguyen, Nam Ngoc1
  • Hoang, Trong Luc2
  • Nguyen, Trang Hong3
  • Le, Phuong Thi1
  • Nguyen, Chi Hung1
  • Tran, Viet Vinh1
  • Chu, Hoang Ha3, 4
  • Hoang, Ha1, 3
  • 1 Centre for DNA Identification, Institute of Biotechnology, Vietnam Academy of Science and Technology, Co Nhue, Hanoi 100000, Vietnam.
  • 2 Department of Forensic Science, People's Police Academy, Hanoi 100000, Vietnam.
  • 3 National Key Laboratory of Gene Technology, Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi 100000, Vietnam.
  • 4 Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi 100000, Vietnam.
Published Article
Annals of Human Biology
Informa UK (Taylor & Francis)
Publication Date
Nov 27, 2022
DOI: 10.1080/03014460.2022.2152488
PMID: 36437685


Background: Mitochondrial DNA (mtDNA) analysis has been used in forensics and requires well-established population databases for statistical interpretations. However, high-quality mtDNA data from Vietnamese population samples have been limited.Aim: To examine the mtDNA sequences and haplogroup compositions of a Vietnamese population to provide an mtDNA dataset that can further be used to construct a Vietnamese-specific reference database.Subjects and methods: A total of 173 Vietnamese individuals were analysed for two hypervariable regions (HVI and HVII) of mtDNA. Forensic parameters were calculated and haplogroup assignment was performed based on the resulting mtDNA haplotypes. Genetic relationships between the Vietnamese and other Asian populations were investigated through principal component analysis (PCA) and pairwise Fst.Results: The Vietnamese population sample consisted of 145 different haplotypes with a random match probability of 0.96%, a power of discrimination of 0.9904, and a haplotype diversity of 0.9962. The samples were assigned to 83 haplogroups that were commonly reported in Asia. PCA and pairwise Fst revealed close relationships of the Vietnamese population to other Asian populations, especially to populations in proximity.Conclusion: The results from this study can contribute to the current genetic information content as a supplementary mtDNA reference dataset for forensic investigations and phylogenetic research.

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