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Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

Authors
  • Yamazaki, Takahiro1
  • Kirchmair, Alexander2
  • Sato, Ai1
  • Buqué, Aitziber1
  • Rybstein, Marissa1
  • Petroni, Giulia1
  • Bloy, Norma1
  • Finotello, Francesca2
  • Stafford, Lena1
  • Navarro Manzano, Esther3, 4, 5
  • Ayala de la Peña, Francisco3, 4, 5
  • García-Martínez, Elena3, 4, 6
  • Formenti, Silvia C.1, 7
  • Trajanoski, Zlatko2
  • Galluzzi, Lorenzo1, 7, 8, 9, 10
  • 1 Weill Cornell Medical College, New York, NY, USA , New York (United States)
  • 2 Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria , Innsbruck (Austria)
  • 3 Hospital Universitario Morales Meseguer, Murcia, Spain , Murcia (Spain)
  • 4 Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain , Murcia (Spain)
  • 5 Universidad de Murcia, Murcia, Spain , Murcia (Spain)
  • 6 Universidad Católica San Antonio de Murcia, Guadalupe, Spain , Guadalupe (Spain)
  • 7 Sandra and Edward Meyer Cancer Center, New York, NY, USA , New York (United States)
  • 8 Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA , New York (United States)
  • 9 Yale University School of Medicine, New Haven, CT, USA , New Haven (United States)
  • 10 Université Paris Descartes/Paris V, Paris, France , Paris (France)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 03, 2020
Volume
21
Issue
10
Pages
1160–1171
Identifiers
DOI: 10.1038/s41590-020-0751-0
Source
Springer Nature
License
Yellow

Abstract

Autophagy controls cellular homeostasis and influences immune responses. Galluzzi and colleagues show that tumor cell autophagy opposes inflammatory cell death following radiation therapy and can be inhibited to enhance antitumor responses.

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