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Mitochondrial distribution and inheritance.

Authors
  • Berger, K H
  • Yaffe, M P
Type
Published Article
Journal
Experientia
Publication Date
Dec 15, 1996
Volume
52
Issue
12
Pages
1111–1116
Identifiers
PMID: 8988253
Source
Medline
License
Unknown

Abstract

Mechanisms mediating the inheritance of mitochondria are poorly understood, but recent studies with the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe have begun to identify components that facilitate this essential process. These components have been identified through the analysis of conditional yeast mutants that display aberrant mitochondrial distribution at restrictive conditions. The analysis of these mutants has uncovered several novel proteins that are localized either to cytoskeletal structures or to the mitochondria themselves. Many mitochondrial inheritance mutants also show altered mitochondrial morphology and defects in maintenance of the mitochondrial genome. Although some inheritance components and mechanisms appear to function specifically in certain types of cells, other conserved proteins are likely to mediate mitochondrial behavior in all eukaryotic cells.

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