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Mitochondrial defects in cancer

Authors
  • Carew, Jennifer S1, 2
  • Huang, Peng1, 2
  • 1 The University of Texas M. D. Anderson Cancer Center, Department of Molecular Pathology, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA , Houston
  • 2 University of Texas Health Sciences Center, The Graduate School of Biomedical Sciences, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA , Houston
Type
Published Article
Journal
Molecular Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Dec 09, 2002
Volume
1
Issue
1
Identifiers
DOI: 10.1186/1476-4598-1-9
Source
Springer Nature
Keywords
License
Yellow

Abstract

Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progression of cancer. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in various types of cancer, and offer some perspective as to the emergence of mtDNA mutations, their functional consequences in cancer development, and therapeutic implications.

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