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Mitochondria: from cell death executioners to regulators of cell differentiation.

Authors
  • Kasahara, Atsuko1
  • Scorrano, Luca2
  • 1 Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland. , (Switzerland)
  • 2 Department of Biology, University of Padua, 35121 Padua, Italy; Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padua, Italy. Electronic address: [email protected] , (Italy)
Type
Published Article
Journal
Trends in cell biology
Publication Date
December 2014
Volume
24
Issue
12
Pages
761–770
Identifiers
DOI: 10.1016/j.tcb.2014.08.005
PMID: 25189346
Source
Medline
Keywords
License
Unknown

Abstract

Most, if not all mitochondrial functions, including adenosine-5'-triphosphate (ATP) production and regulation of apoptosis and Ca(2+) homeostasis, are inextricably linked to mitochondrial morphology and dynamics, a process controlled by a family of GTP-dependent dynamin related 'mitochondria-shaping' proteins. Mitochondrial fusion and fission directly influence mitochondrial metabolism, apoptotic and necrotic cell death, autophagy, muscular atrophy and cell migration. In this review, we discuss the recent evidence indicating that mitochondrial dynamics influence complex signaling pathways, affect gene expression and define cell differentiation. These findings extend the importance of mitochondria to developmental biology, far beyond their mere bioenergetic role.

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