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Mitochondria distinguish granule-stored from de novo synthesized tumor necrosis factor secretion in human mast cells.

Authors
  • Zhang, Bodi
  • Weng, Zuyi
  • Sismanopoulos, Nikolaos
  • Asadi, Sharhzad
  • Therianou, Anastasia
  • Alysandratos, Konstantinos-Dionysios
  • Angelidou, Asimenia
  • Shirihai, Orian
  • Theoharides, Theoharis C
Type
Published Article
Journal
International Archives of Allergy and Immunology
Publisher
S. Karger AG
Publication Date
Jan 01, 2012
Volume
159
Issue
1
Pages
23–32
Identifiers
DOI: 10.1159/000335178
PMID: 22555146
Source
Medline
License
Unknown

Abstract

Our findings indicate that unique mitochondrial functions distinguish granule-stored from newly synthesized TNF release from human mast cells, thus permitting the versatile involvement of mast cells in different biological processes.

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