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Misuse of the Naranjo Adverse Drug Reaction Probability Scale in toxicology.

Authors
  • Seger, D
  • Barker, K
  • McNaughton, C
Type
Published Article
Journal
Clinical toxicology (Philadelphia, Pa.)
Publication Date
Jul 01, 2013
Volume
51
Issue
6
Pages
461–466
Identifiers
DOI: 10.3109/15563650.2013.811588
PMID: 23777343
Source
Medline
License
Unknown

Abstract

Adverse events that occur in overdose patients are excluded from the definition of ADR. Yet in case reports or series of overdose patients, the Naranjo Scale has been applied to assess the probability an event was caused by the ingested drug or therapeutic modality. This application of the Naranjo Scale is not scientifically valid and may lead to erroneous conclusions. There is no evidence to support the application of the Naranjo scale to any events that occur in overdose patients.

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