Affordable Access

deepdyve-link
Publisher Website

The Missing lnc(RNA) between the pancreatic β-cell and diabetes.

Authors
  • Kameswaran, Vasumathi
  • Kaestner, Klaus H
Type
Published Article
Journal
Frontiers in Genetics
Publisher
Frontiers Media SA
Publication Date
Jan 01, 2014
Volume
5
Pages
200–200
Identifiers
DOI: 10.3389/fgene.2014.00200
PMID: 25071830
Source
Medline
Keywords
License
Unknown

Abstract

Diabetes mellitus represents a group of complex metabolic diseases that result in impaired glucose homeostasis, which includes destruction of β-cells or the failure of these insulin-secreting cells to compensate for increased metabolic demand. Despite a strong interest in characterizing the transcriptome of the different human islet cell types to understand the molecular basis of diabetes, very little attention has been paid to the role of long non-coding RNAs (lncRNAs) and their contribution to this disease. Here we summarize the growing evidence for the potential role of these lncRNAs in β-cell function and dysregulation in diabetes, with a focus on imprinted genomic loci.

Report this publication

Statistics

Seen <100 times