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Misreading of the argI message in Escherichia coli.

Authors
Type
Published Article
Journal
FEMS microbiology letters
Publication Date
Volume
100
Issue
1-3
Pages
141–145
Identifiers
PMID: 1282483
Source
Medline
License
Unknown

Abstract

It has previously been shown that either phenylalanine codon, UUU or UUC, could be misread as leucine during phenylalanine starvation, if the codons encoded residue 8 of the Escherichia coli argI gene product, ornithine transcarbamylase (OTC). However, no leucine misincorporation was detected when either of these same codons encoded residue 3. Here we report that leucine misincorporation can be directed by a UUU codon for residue 3 of OTC during phenylalanine starvation, if the argI gene has been mutated so that the codon preceding the UUU has been changed from the rarely used glycine codon GGG to the more commonly used GGC.

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