Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma.
School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086 Australia ; Olivia Newton-John Cancer Research Institute, Level 5 ONJCWC, 145 Studley Road, Heidelberg, VIC 3084 Australia.
Cancer Immunobiology Laboratory, Ludwig Institute for Cancer Research, Melbourne-Austin Branch, Melbourne, Australia.
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC Australia.
- Published Article
Journal for ImmunoTherapy of Cancer
Springer (Biomed Central Ltd.)
- Publication Date
Our results illustrate a little-studied mechanism of immune escape by tumor cells which, with appropriate understanding and treatment, may be reversible. These data have implications for the design of cancer vaccines and adoptive T cell therapies.
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This record was last updated on 07/07/2017 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/26885372