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Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma.

Authors
  • Woods, Katherine1
  • Knights, Ashley J2
  • Anaka, Matthew2
  • Schittenhelm, Ralf B3
  • Purcell, Anthony W3
  • Behren, Andreas1
  • Cebon, Jonathan1
  • 1 School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086 Australia ; Olivia Newton-John Cancer Research Institute, Level 5 ONJCWC, 145 Studley Road, Heidelberg, VIC 3084 Australia.
  • 2 Cancer Immunobiology Laboratory, Ludwig Institute for Cancer Research, Melbourne-Austin Branch, Melbourne, Australia.
  • 3 Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC Australia.
Type
Published Article
Journal
Journal for ImmunoTherapy of Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
2016
Volume
4
Pages
10–10
Identifiers
DOI: 10.1186/s40425-016-0111-7
PMID: 26885372
Source
Medline
Keywords
License
Unknown

Abstract

Our results illustrate a little-studied mechanism of immune escape by tumor cells which, with appropriate understanding and treatment, may be reversible. These data have implications for the design of cancer vaccines and adoptive T cell therapies.

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