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Mismanagement of Wilson's disease as psychotic disorder

Authors
  • Reza Bidaki
  • Mina Zarei
  • S. M. Mahdy Mirhosseini
  • Samar Moghadami
  • Maral Hejrati
  • Marjan Kohnavard
  • Behnam Shariati
Journal
Advanced Biomedical Research
Publisher
Medknow Publications
Publication Date
Jan 01, 2012
Volume
1
Issue
1
Identifiers
DOI: 10.4103/2277-9175.100182
Keywords

Abstract

Wilson's disease (WD) or hepatolenticular degeneration is an inherited neurodegenerative disorder of copper metabolism (autosomal recessive, chromosome13). Psychiatric disorders in WD include dementia, characterized by mental slowness, poor concentration, and memory impairment. Symptoms may progress rapidly, especially in younger patients, but are more often gradual in development with periods of remission and exacerbation. Delusional disorder and schizophrenia-like psychosis are rare forms of psychiatric presentation. In this report, the patient with WD presented by psychosis symptoms and treated mistaken as schizophrenia for almost ten years. Although he has treated with antipsychotics, he had periods of remissions and relapses and never was symptoms free. Since psychosis can be the manifestation of medical diseases such as WD, overall view of these patients is necessary and medical diseases should be considered as a differential diagnosis.

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