Affordable Access

deepdyve-link
Publisher Website

MiR-767 promoted cell proliferation in human melanoma by suppressing CYLD expression.

Authors
  • Zhang, Kejin1
  • Guo, Ling2
  • 1 Department of Dermatology, Liaocheng City People's Hospital, Liaocheng City, Shandong Province 252000, People's Republic of China. , (China)
  • 2 Department of Dermatology, Liaocheng City People's Hospital, Liaocheng City, Shandong Province 252000, People's Republic of China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Gene
Publication Date
Jan 30, 2018
Volume
641
Pages
272–278
Identifiers
DOI: 10.1016/j.gene.2017.10.055
PMID: 29054757
Source
Medline
Keywords
License
Unknown

Abstract

MicroRNAs (miRNAs) have emerged as critical regulators for cancer development and progression of human melanoma. However, the potential molecular mechanism of miR-767 in human melanoma has not been intensively investigated. In this present study, we confirmed that miR-767 was frequently up-regulated in human melanoma tissues and cell lines. Ectopic expression of miR-767 promoted cell proliferation in human melanoma cell lines A375 and WM35, whereas miR-767-in reversed the function. Bioinformatics analysis revealed that cylindromatosis (CYLD) was hypothesized to be a possible target gene of miR-767, and this was confirmed by luciferase activity assay. Knockdown of CYLD counteracted the proliferation arrest by miR-767-in in melanoma cells A375 and WM35. In conclusion, our study indicated that miR-767 acted as a role of tumor promoter by targeting CYLD in human melanoma, and might serve as a prognostic or therapeutic target for human melanoma.

Report this publication

Statistics

Seen <100 times