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miR-4721, Induced by EBV-miR-BART22, Targets GSK3β to Enhance the Tumorigenic Capacity of NPC through the WNT/β-catenin Pathway

Authors
  • Tang, ZiBo1
  • Chen, WeiFeng1
  • Xu, Yan1
  • Lin, Xian1
  • Liu, Xiong2
  • Li, YongHao1
  • Liu, YiYi1
  • Luo, ZhiJian1
  • Liu, Zhen3
  • Fang, WeiYi1
  • Zhao, MengYang1, 4
  • 1 Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, 510315 Guangzhou, China
  • 2 Department of Otolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, China
  • 3 Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, 511436 Guangzhou, China
  • 4 Department of Oncology, The People’s Hospital of Zhengzhou University, 450003 Zhengzhou, China
Type
Published Article
Journal
Molecular Therapy — Nucleic Acids
Publisher
Elsevier
Publication Date
Sep 23, 2020
Volume
22
Pages
557–571
Identifiers
DOI: 10.1016/j.omtn.2020.09.021
PMCID: PMC7566007
Source
PubMed Central
Keywords
License
Unknown

Abstract

MicroRNAs play an important role in the tumorigenesis of nasopharyngeal carcinoma (NPC), with the regulations between two miRNAs being less reported. Tang and colleagues demonstrated that miR-4721, induced by EBV-miR-BART22, facilitates the progression of NPC. Further experiments both in vitro and in vivo clarified the underlying mechanism.

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