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miR-193: A new weapon against cancer.

Authors
  • Khordadmehr, Monireh1
  • Shahbazi, Roya1
  • Sadreddini, Sanam2
  • Baradaran, Behzad2, 3
  • 1 Department of Pathology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran. , (Iran)
  • 2 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , (Iran)
  • 3 Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. , (Iran)
Type
Published Article
Journal
Journal of Cellular Physiology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Aug 01, 2019
Volume
234
Issue
10
Pages
16861–16872
Identifiers
DOI: 10.1002/jcp.28368
PMID: 30779342
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which structurally consist of 19-22 nucleotides in length and functionally act as one of the main regulators of gene expression in important biological and physiological contexts like cell growth, apoptosis, proliferation, differentiation, movement (cell motility), and angiogenesis as well as disease formation and progression importantly in cancer cell invasion, migration, and metastasis. Among these notable tiny molecules, many studies recently presented the important role of the miR-193 family comprising miR-193a-3p, miR-193a-5p, miR-193b-3p, and miR-193b-5p in health and disease biological processes by interaction with special targeting and signaling, which mainly contribute as a tumor suppressor. Therefore, in the present paper, we review the functional role of this miRNA family in both health and disease conditions focusing on various tumor developments, diagnoses, prognoses, and treatment. © 2019 Wiley Periodicals, Inc.

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