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MiR-122-5p and miR-326-3p: Potential novel biomarkers for early detection of cadmium exposure.

Authors
  • Yuan, Wenya1
  • Liu, Lili2
  • Liang, Lixia1
  • Huang, Ke1
  • Deng, Yaotang1
  • Dong, Ming2
  • Chen, Jiabin2
  • Wang, Guanghai3
  • Zou, Fei4
  • 1 Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China. , (China)
  • 2 Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China. , (China)
  • 3 Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China. Electronic address: [email protected] , (China)
  • 4 Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Gene
Publication Date
Jan 15, 2020
Volume
724
Pages
144156–144156
Identifiers
DOI: 10.1016/j.gene.2019.144156
PMID: 31626960
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cadmium is a common environmental and occupational pollutant and can produce toxic effects in a range of organs, especially in kidneys, after long-term exposure. MicroRNAs are ideal candidate biomarkers for various types of disorders, including renal diseases. In this study, we profiled the global miRNA expressions in rat kidneys using miRNA microarrays and found a collection of differentially expressed miRNAs induced by cadmium exposure. Among all of the candidate miRNAs, we identified miR-122-5p and miR-326-3p as early biomarkers for cadmium-induced nephrotoxicity. The two-miRNA signature was validated by quantitative real-time PCR in HK-2 and NRK-52E cells, rat kidney, serum and urine samples, and serum of an occupational population. Our results indicate that miR-122-5p and miR-326-3p may be potential biomarkers for cadmium exposure. Copyright © 2019 Elsevier B.V. All rights reserved.

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