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MiR-20a is upregulated in anaplastic thyroid cancer and targets LIMK1.

Authors
  • Xiong, Yin
  • Zhang, Lisa
  • Kebebew, Electron
Type
Published Article
Journal
PLoS ONE
Publisher
Public Library of Science
Publication Date
Jan 01, 2014
Volume
9
Issue
5
Identifiers
DOI: 10.1371/journal.pone.0096103
PMID: 24858712
Source
Medline
License
Unknown

Abstract

To our knowledge, this is the first study to demonstrate that miR-20a plays a role as a tumor suppressor in thyroid cancer cells and targets LIMK1. Our findings suggest the upregulated expression of miR-20a in anaplastic thyroid cancer counteracts thyroid cancer progression and may have therapeutic potential.

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