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MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test.

Authors
  • Boston, Ray C
  • Stefanovski, Darko
  • Moate, Peter J
  • Sumner, Anne E
  • Watanabe, Richard M
  • Bergman, Richard N
Type
Published Article
Journal
Diabetes technology & therapeutics
Publication Date
Jan 01, 2003
Volume
5
Issue
6
Pages
1003–1015
Identifiers
PMID: 14709204
Source
Medline
License
Unknown

Abstract

The Bergman Minimal Model enables estimation of two key indices of glucose/insulin dynamics: glucose effectiveness and insulin sensitivity. In this paper we describe MINMOD Millennium, the latest Windows-based version of minimal model software. Extensive beta testing of MINMOD Millennium has shown that it is user-friendly, fully automatic, fast, accurate, reproducible, repeatable, and highly concordant with past versions of MINMOD. It has a simple interface, a comprehensive help system, an input file editor, a file converter, an intelligent processing kernel, and a file exporter. It provides publication-quality charts of glucose and insulin and a table of all minimal model parameters and their error estimates. In contrast to earlier versions of MINMOD and some other minimal model programs, Millennium provides identified estimates of insulin sensitivity and glucose effectiveness for almost every subject.

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