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Minireview: Nuclear receptor-controlled steroid hormone synthesis and metabolism.

Authors
  • He, Jinhan
  • Cheng, Qiuqiong
  • Xie, Wen
Type
Published Article
Journal
Molecular Endocrinology
Publisher
The Endocrine Society
Publication Date
Jan 01, 2010
Volume
24
Issue
1
Pages
11–21
Identifiers
DOI: 10.1210/me.2009-0212
PMID: 19762543
Source
Medline
License
Unknown

Abstract

Steroid hormones are essential in normal physiology whereas disruptions in hormonal homeostasis represent an important etiological factor for many human diseases. Steroid hormones exert most of their functions through the binding and activation of nuclear hormone receptors (NRs or NHRs), a superfamily of DNA-binding and often ligand-dependent transcription factors. In recent years, accumulating evidence has suggested that NRs can also regulate the biosynthesis and metabolism of steroid hormones. This review will focus on the recent progress in our understanding of the regulatory role of NRs in hormonal homeostasis and the implications of this regulation in physiology and diseases.

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