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A minimalistic tetrapeptide amphiphile scaffold for transmembrane pores with a preference for sodium

Authors
  • BASAK, D
  • SRIDHAR, S
  • BERA, AK
  • MADHAVAN, N
Publication Date
Nov 28, 2017
Identifiers
DOI: 10.1016/j.bmcl.2017.04.081
OAI: oai:dsapce.library.iitb.ac.in:123456789/18971
Source
DSpace at IIT Bombay
Keywords
License
Unknown
External links

Abstract

Synthetic channels or pores that are easy to synthesize, stable and cation-selective are extremely attractive for the development of therapeutics and materials. Herein, we report a pore developed from a small tetrapeptide scaffold that shows a preference for sodium over lithium/potassium. The sodium selectivity is attributed to the appended oligoether tail at the C-terminus. A peptide dimer is proposed as the predominant cation-transporting pore. Such pyridine containing stable pores can be potentially utilized for the pH modulated ion transport. (C) 2017 Elsevier Ltd. All rights reserved.

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