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Minimal functional brain differences between older adults with and without mild cognitive impairment during the stroop.

Authors
  • Puente, Antonio Nicolas
  • Faraco, Carlos
  • Terry, Douglas P
  • Brown, Courtney
  • Miller, L Stephen
Type
Published Article
Journal
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
Publication Date
Jan 01, 2014
Volume
21
Issue
3
Pages
346–369
Identifiers
DOI: 10.1080/13825585.2013.824065
PMID: 23984890
Source
Medline
License
Unknown

Abstract

This investigation compared the neural correlates of inhibition in normal older adults (OAs) and OAs with mild cognitive impairment (MCI). It was hypothesized the MCI group would require a greater amount of resources for inhibition, and therefore display greater functional activation in specific regions of interest (ROIs). Twenty-six OAs without and 17 with MCI completed the Stroop task during functional neuroimaging, and completed additional out-of-scanner neuropsychological measures. During inhibition, there were minimal functional Magnetic Resonance Imaging (fMRI) differences found between groups in a priori specified ROIs and with post-hoc multiple regression analyses. However, these minimal differences did not survive corrected thresholds. Robust differences were found with several tasks of a neuropsychological screening battery. The results of this study suggest only very minimal group differences in fMRI activation during inhibition which may not reliably identify MCI, and this condition may be best detected by traditional neuropsychological techniques.

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