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[Mineralocorticoid receptor].

Authors
  • Nishiyama, Akira1
  • Kiyomoto, Hideyasu
  • Kohno, Masakazu
  • 1 Department of Pharmacology, Kagawa University Medical School.
Type
Published Article
Journal
Nihon rinsho. Japanese journal of clinical medicine
Publication Date
Apr 01, 2009
Volume
67
Issue
4
Pages
695–700
Identifiers
PMID: 19348230
Source
Medline
License
Unknown

Abstract

Recent clinical trials have indicated the utility of mineralocorticoid receptor (MR) antagonists in patients with cardiovascular and renal diseases. Experiments studies have shown that chronic treatment with aldosterone resulted in severe cardiac and renal injuries, which were ameliorated by MR antagonists. In vitro studies also showed that MR is highly expressed in cultured vascular endothelial cells, vascular smooth muscle cells, cardiomyocytes, mesangial cells, glomerular epithelial cells, renal fibroblasts and proximal tubular cells. In these cells, aldosterone-induced cell injuries were prevented by MR antagonists. These accumulating data support the notion that aldosterone is involved in the pathogenesis of cardiovascular and renal injuries through local MR activation.

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