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Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers.

Authors
  • Patch, James A
  • Barron, Annelise E
Type
Published Article
Journal
Current Opinion in Chemical Biology
Publisher
Elsevier
Publication Date
Dec 01, 2002
Volume
6
Issue
6
Pages
872–877
Identifiers
PMID: 12470744
Source
Medline
License
Unknown

Abstract

Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential therapeutic application. Cationic, facially amphipathic helical beta-peptide oligomers have been developed as magainin mimetics. Non-natural mimics of HIV-Tat protein, lung surfactant proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in beta-peptides and peptoids may herald the creation of entirely artificial proteins.

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