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mig-14 Is a Horizontally Acquired, Host-Induced Gene Required for Salmonella enterica Lethal Infection in the Murine Model of Typhoid Fever

Authors
  • Raphael H. Valdivia
  • Daniela M. Cirillo
  • Anthea K. Lee
  • Donna M. Bouley
  • Stanley Falkow
Publisher
American Society for Microbiology
Publication Date
Dec 01, 2000
Source
PMC
Keywords
License
Unknown

Abstract

We have characterized a host-induced virulence gene, mig-14, that is required for fatal infection in the mouse model of enteric fever. mig-14 is present in all Salmonella enterica subspecies I serovars and maps to a region of the chromosome that appears to have been acquired by horizontal transmission. A mig-14 mutant replicated in host tissues early after infection but was later cleared from the spleens and livers of infected animals. Bacterial clearance by the host occurred concomitantly with an increase in gamma interferon levels and recruitment of macrophages, but few neutrophils, to the infection foci. We hypothesize that the mig-14 gene product may repress immune system functions by interfering with normal cytokine expression in response to bacterial infections.

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