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MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia.

Authors
  • Awandare, Gordon A
  • Martinson, Jeremy J
  • Were, Tom
  • Ouma, Collins
  • Davenport, Gregory C
  • Ong'echa, John M
  • Wang, Wenkui
  • Leng, Lin
  • Ferrell, Robert E
  • Bucala, Richard
  • Perkins, Douglas J
Type
Published Article
Journal
The Journal of infectious diseases
Publication Date
Aug 15, 2009
Volume
200
Issue
4
Pages
629–637
Identifiers
DOI: 10.1086/600894
PMID: 19591577
Source
Medline
License
Unknown

Abstract

The findings demonstrate that variation in the MIF promoter influences susceptibility to SMA and peripheral MIF production. However, the MIF -173 and -794 polymorphisms appear to have both independent and interactive effects on different measures of disease severity, suggesting that MIF plays a complex role in malarial pathogenesis.

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