Affordable Access

deepdyve-link
Publisher Website

Mid-pregnancy maternal immune activation increases Pax6-positive and Tbr2-positive neural progenitor cells and causes integrated stress response in the fetal brain in a mouse model of maternal viral infection

Authors
  • Tsukada, Tsuyoshi1, 2
  • Sakata-Haga, Hiromi1
  • Shimada, Hiroki3
  • Shoji, Hiroki4
  • Hatta, Toshihisa1
  • 1 Department of Anatomy, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
  • 2 Department of Neurosurgery, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
  • 3 Department of Medical Science, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
  • 4 Department of Biology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
Type
Published Article
Journal
IBRO Neuroscience Reports
Publisher
Elsevier
Publication Date
Aug 03, 2021
Volume
11
Pages
73–80
Identifiers
DOI: 10.1016/j.ibneur.2021.07.003
PMID: 34409402
PMCID: PMC8363822
Source
PubMed Central
Keywords
Disciplines
  • Research Paper
License
Unknown

Abstract

• MIA increases Pax6-positive and Tbr2-positive neural progenitor cells. • MIA impaired the process of neurogenesis from as early as the acute stage. • MIA upregulated Atf4, an effector of integrated stress response, in the fetal brain.

Report this publication

Statistics

Seen <100 times