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Microvascular density in non-Hodgkin B-cell lymphomas measured using digital morphometry.

Authors
Type
Published Article
Journal
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Publication Date
Volume
53
Issue
1
Pages
67–71
Identifiers
PMID: 22395502
Source
Medline
License
Unknown

Abstract

According to literature data, our knowledge and understanding of angiogenesis grew rapidly from early studies such as Folkman's classic paper. Many studies showed that angiogenesis plays a key role in the biology of tumors and therefore the study of angiogenesis might open new therapeutic possibilities. There have been many studies of angiogenesis in malignant lymphomas, however not as many articles as in other tumor types. Our morphometric studies showed there are statistically significant differences between diffuse large cell lymphoma (DLBCL) and follicular lymphoma (FL) regarding average vascular diameter and that high grade lymphomas tend to have a greater CD34+ endothelial area.

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