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Microtubule formation and the initial association of tubulin dimers.

Authors
  • Foster, K E
  • Rosemeyer, M A
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 1986
Volume
194
Issue
1
Pages
78–84
Identifiers
PMID: 3940892
Source
Medline
License
Unknown

Abstract

Microtubule protein could be prepared in high yield, and could form copious microtubules, in solutions containing glutamate but not in solutions containing only phosphate ions. Correspondingly, tubulin after isolation showed an association equilibrium in the presence of glutamate (or other zwitterions), but not in phosphate buffers. The correlation suggests that this association to tetramers is probably the initial step in the mechanism of microtubule formation.

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