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Microtopography of fear memory consolidation and extinction retrieval within prefrontal cortex and amygdala

  • Jacques, Angela1, 2
  • Chaaya, Nicholas1, 2
  • Hettiarachchi, Chiemi2
  • Carmody, Marie-Louise1, 2
  • Beecher, Kate2, 3
  • Belmer, Arnauld2, 3
  • Chehrehasa, Fatemeh2, 4
  • Bartlett, Selena2, 3
  • Battle, Andrew R.2, 4, 5
  • Johnson, Luke R.1, 2, 6
  • 1 Queensland University of Technology, School of Psychology and Counselling, Brisbane, Australia , Brisbane (Australia)
  • 2 Queensland University of Technology, Translational Research Institute, Institute of Health and Biomedical Innovation, Department of Psychology and Counselling, Brisbane, QLD, Australia , Brisbane (Australia)
  • 3 Queensland University of Technology, School of Clinical Sciences, Brisbane, Australia , Brisbane (Australia)
  • 4 Queensland University of Technology, School of Biomedical Sciences, Brisbane, Australia , Brisbane (Australia)
  • 5 The University of Queensland Diamantina Institute, Brisbane, Australia , Brisbane (Australia)
  • 6 USU School of Medicine, Center for the Study of Traumatic Stress, Department of Psychiatry, Bethesda, MD, USA , Bethesda (United States)
Published Article
Publication Date
Jan 04, 2019
DOI: 10.1007/s00213-018-5068-4
Springer Nature


RationaleThe precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopography of neurons activated during the recall of an extinguished fear memory, as well as the influence of time on this microtopography.MethodsWe used the plasticity-related phosphorylated mitogen-activated protein kinase (pMAPK) to identify neurons activated in the recall of consolidated and extinguished auditory Pavlovian fear memories in rats. Quantitatively matched brain regions were used to investigate activity in the amygdala and prefrontal cortex.ResultsRecall of a consolidated, nonextinguished auditory fear memory resulted in a significantly greater number of activated neurons located in the dorsolateral subdivision of the lateral amygdala (LADL) when recalled 24 h after consolidation but not when recalled 7 days later. We found that the recall of an extinction memory was associated with pMAPK activation in the ventrolateral subdivision of the lateral amygdala (LAVL). Next, we showed that the pattern of pMAPK expression in the prelimbic cortex differed spatially following temporal variation in the recall of that memory. The deep and superficial layers of the pre-limbic cortex were engaged in recent recall of a fear memory, but only the superficial layers were recruited if the recall occurred 7 days later.ConclusionsCollectively, our findings demonstrate a functional microtopography of auditory fear memory during consolidation and extinction at the microanatomical level within the lateral amygdala and medial prefrontal cortex.

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