Affordable Access

deepdyve-link
Publisher Website

Microsporidia Can Acquire Lamin-like Intermediate Filaments and Cell Adhesion Catenin-cadherin Complexes from the Host (?).

Authors
  • Weidner, Earl1
  • Sokolova, Yuliya Y2, 3
  • Overstreet, Robin M4
  • 1 Louisiana State University, Baton Rouge, Louisiana, USA.
  • 2 Institute of Cytology, St. Petersburg, Russia.
  • 3 The George Washington University, Washington, District of Columbia, USA.
  • 4 Gulf Coast Research Laboratory, University of Southern Mississippi, Ocean Springs, Mississippi, USA.
Type
Published Article
Journal
The Journal of eukaryotic microbiology
Publication Date
Sep 01, 2020
Volume
67
Issue
5
Pages
583–592
Identifiers
DOI: 10.1111/jeu.12811
PMID: 32498127
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

On their spore surfaces, Microsporidia often develop a canopy of filaments with characteristics of intermediate filaments (IF), as we demonstrated in previous studies on Thelohania sp., Ameson michaelis, and Spraguea lophii. Genomic studies indicate that among invertebrates, lamins that may localize in the cytoplasm or nucleus, are the only known IF type. These IFs can bind to the substrate containing cell adhesion molecules (CAMs) cadherins, associated with β and γ catenins. The objects of this study were to determine whether microsporidia have CAMs with the attached IFs on their envelopes and to find out if these proteins are provided by the host. An examination was made for localization of lamins and CAMs on the spores of the mentioned above species and Anncaliia algerae, plus in the host animals. Then, we determined whether the spores of A. michaelis and A. algerae could bind vertebrate nuclear lamin onto the spore surface. We also tested transgenic Drosophila melanogaster stocks bearing cadherin-GFP to see whether developing A. algerae parasites in these hosts could acquire host CAMs. The tests were positive for all these experiments. We hypothesize that microsporidia are able to acquire host lamin IFs and cell adhesion catenin-cadherin complexes from the host. © 2020 International Society of Protistologists.

Report this publication

Statistics

Seen <100 times