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Microsphere distribution in the pancreas of anesthetized rats. Alloxan stimulates the blood flow to all islets whereas glucose only affects the blood perfusion of a subgroup of islets.

Authors
  • Jansson, L
Type
Published Article
Journal
International journal of pancreatology : official journal of the International Association of Pancreatology
Publication Date
Aug 01, 1996
Volume
20
Issue
1
Pages
69–74
Identifiers
PMID: 8872526
Source
Medline
License
Unknown

Abstract

Alloxan reduced whole pancreatic blood flow by 50%, but almost doubled islet blood flow. Glucose did not affect whole pancreatic blood flow, but increased islet blood flow 100%. Approximately 10% of the islets in control and glucose-injected rats contained microspheres, compared with about 25% in alloxan-injected rats (P < 0.001). When the islets containing a certain number of microspheres were compared, alloxan induced a homogeneous shift of the curve to the right, i.e., increased the number of islets that contained all amounts of microspheres. Glucose preferentially increased only the fraction of islets containing > or = 3 microspheres.

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