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A microscopic technique to study kinetics and concentration-response of drug-induced caspase-3 activation on a single cell level.

Authors
  • Werner, Jens Martin
  • Steinfelder, Hans Jürgen
Type
Published Article
Journal
Journal of pharmacological and toxicological methods
Publication Date
Jan 01, 2008
Volume
57
Issue
2
Pages
131–137
Identifiers
PMID: 18086538
Source
Medline
License
Unknown

Abstract

Thus, visual detection of caspase activation in each affected cells enabled a more careful evaluation of the concentration- and time-dependence of drug-induced apoptosis which should also be useful with other experimental or standard agents or with other tumour cells.

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