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Microscopic enteritis and pathomechanism of malabsorption

Authors
  • Rostami, Kamran1
  • Al Dulaimi, David2
  • Rostami Nejad, Mohammad3
  • Villanacci, Vincenzo4
  • Danciu, Mihai5
  • 1 University of Birmingham, School of Medicine, Birmingham, UK , Birmingham (United Kingdom)
  • 2 Alexander Hospital, Department of Gastroenterology, Redditch, UK , Redditch (United Kingdom)
  • 3 Shaheed Beheshti University M.C., Research Center of Gastroenterology and Liver disease, Tehran, Iran , Tehran (Iran)
  • 4 University of Brescia, 2nd Department of Pathology, Spedali Civili, Brescia, Italy , Brescia (Italy)
  • 5 “Gr. T. Poparrd University of Medicine and Pharmacy, Iasi, Romania , Iasi (Romania)
Type
Published Article
Journal
Autoimmunity Highlights
Publisher
Springer International Publishing
Publication Date
May 01, 2010
Volume
1
Issue
1
Pages
37–38
Identifiers
DOI: 10.1007/s13317-010-0006-4
Source
Springer Nature
Keywords
License
Yellow

Abstract

Microscopic enteritis (ME) is the stage of microscopic and sub-microscopic changes (microenteropathy) associated with the symptoms of gluten sensitive enteropathy leading to micronutrient deficiencies. It is characterized by subtle mucosal abnormalities without prominent inflammation, villous effacement, erosions or ulcerations on conventional light microscopy. The intraepithelial lymphocytes are usually in normal range <25/100 enterocytes (microenteropathy) or increased (lymphocytic enteritis). ME is the entity behind atypical forms of CD previously known as potential and latent CD. Systemic inflammation predominantly is found to be engaged in pathophysiology of micro-nutrient deficiency even in absence of macroscopic mucosal changes.

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