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Microsatellite instability is linked to loss of hMLH1 expression in advanced gastric cancers: lack of a relationship with the histological type and phenotype.

Authors
  • Mizoshita, Tsutomu
  • Tsukamoto, Tetsuya
  • Cao, Xueyuan
  • Otsuka, Takafumi
  • Ito, Seiji
  • Takahashi, Emiko
  • Nakamura, Shigeo
  • Nakamura, Tsuneya
  • Yamamura, Yoshitaka
  • Tatematsu, Masae
Type
Published Article
Journal
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Publication Date
Jan 01, 2005
Volume
8
Issue
3
Pages
164–172
Identifiers
PMID: 16086119
Source
Medline
License
Unknown

Abstract

Our data support the hypothesis that, phenotypically, some MSI-positive differentiated gastric cancers of gastric foveolar phenotypic expression may easily change, from gastric to intestinal phenotypic expression, also changing, histologically, from differentiated to undifferentiated type with progression.

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