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MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes

Authors
  • Nigi, Laura
  • Grieco, Giuseppina Emanuela
  • Ventriglia, Giuliana
  • Brusco, Noemi
  • Mancarella, Francesca
  • Formichi, Caterina
  • Dotta, Francesco
  • Sebastiani, Guido
Publication Date
Nov 22, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

such alterations have been highlighted in multiple insulin target organs including liver, muscles, and adipose tissue. Indirectly, miRNAs have been identified as modulators of inflammation-derived insulin resistance, by controlling/tuning the activity of innate immune cells in insulin target tissues. Here, we review main findings on miRNA functions as modulators of insulin signaling in physiologic- or in T2D insulin resistance- status. Additionally, we report the latest hypotheses of prospective therapies involving miRNAs as potential targets for future drugs in T2D.

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