Affordable Access

deepdyve-link
Publisher Website

MicroRNAs as potential therapeutics for treating spinal cord injury.

Authors
  • Yan, Hualin
  • Hong, Peiwei
  • Jiang, Mei
  • Li, Hedong
Type
Published Article
Journal
Neural Regeneration Research
Publisher
Medknow Publications
Publication Date
Jun 15, 2012
Volume
7
Issue
17
Pages
1352–1359
Identifiers
DOI: 10.3969/j.issn.1673-5374.2012.17.011
PMID: 25657667
Source
Medline
Keywords
License
Unknown

Abstract

MicroRNAs are a class of recently discovered, small non-coding RNAs that have been shown to play essential roles in a vast majority of biological processes. Very little is known about the role of microRNAs during spinal cord injury. This review summarizes the changes in expression levels of microRNAs after spinal cord injury. These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. Given their small size and specificity of action, microRNAs could be potential therapeutics for treating spinal cord injury in the future. There are rapidly developing techniques for manipulating microRNA levels in animals; we review different chemical modification and delivery strategies. These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic.

Report this publication

Statistics

Seen <100 times