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MicroRNAs as potential therapeutics for treating spinal cord injury.

Authors
Type
Published Article
Journal
Neural Regeneration Research
1673-5374
Publisher
Medknow Publications
Publication Date
Volume
7
Issue
17
Pages
1352–1359
Identifiers
DOI: 10.3969/j.issn.1673-5374.2012.17.011
PMID: 25657667
Source
Medline
Keywords
  • Antagomir
  • Anti-Mir
  • Axonal Regeneration
  • Micrornas
  • Neural Regeneration
  • Reactive Astrogliosis
  • Reviews
  • Spinal Cord Injury

Abstract

MicroRNAs are a class of recently discovered, small non-coding RNAs that have been shown to play essential roles in a vast majority of biological processes. Very little is known about the role of microRNAs during spinal cord injury. This review summarizes the changes in expression levels of microRNAs after spinal cord injury. These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. Given their small size and specificity of action, microRNAs could be potential therapeutics for treating spinal cord injury in the future. There are rapidly developing techniques for manipulating microRNA levels in animals; we review different chemical modification and delivery strategies. These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic.

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