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MicroRNAs in pancreatic malignancy: Progress and promises

Authors
  • Srivastava, Sanjeev K.
  • Arora, Sumit
  • Singh, Seema
  • Bhardwaj, Arun
  • Averett, Courey
  • Singh, Ajay P.1, 2, 3, 2
  • 1 Mitchell Cancer Institute
  • 2 University of South Alabama
  • 3 Department of Biochemistry and Molecular Biology
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Feb 13, 2014
Identifiers
DOI: 10.1016/j.canlet.2014.02.015
Source
Elsevier
Keywords
License
Unknown

Abstract

Despite progress in recent years, pancreatic cancer still remains a major clinical challenge. Its incidence and mortality rates have been on consistent rise underscoring the critical need for novel diagnostic, prognostic and therapeutic tools for its effective management. Recent studies have demonstrated that microRNAs (miRNAs/miRs) are deregulated in a variety of malignancies, including pancreatic cancer, and play a significant role in the initiation, progression and metastasis. Furthermore, their vital involvement in the therapeutic resistance of cancer has also been established. Hence, there has been enormous interest worldwide in investigating the roles of miRNAs in pancreatic cancer pathogenesis and exploiting their utility for clinical benefit. In this review, we summarize current knowledge on the role of miRNAs in pancreatic cancer and discuss their potential use as diagnostic and prognostic biomarkers, and as novel targets for development of effective therapeutic strategies.

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