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MicroRNAs and glial cell development.

Authors
  • 1
  • 1 Institute of Developmental and Regenerative Biology, Hangzhou Normal University, College of Life and Environmental Sciences, Hangzhou, Zhejiang, China. , (China)
Type
Published Article
Journal
The Neuroscientist
1089-4098
Publisher
SAGE Publications
Publication Date
Volume
18
Issue
2
Pages
114–118
Identifiers
DOI: 10.1177/1073858411398322
PMID: 21555783
Source
Medline
License
Unknown

Abstract

Mounting evidence indicates that microRNAs (miRNAs) play important roles in the control of glial cell development in the central nervous system. Suppression of miRNA formation disrupts the initial generation of oligodendrocyte progenitor cells from the ventricular neuroprogenitor cells in the embryonic spinal cord. miRNAs also regulate the later events of oligodendrocyte development, including cell proliferation, maturation, and myelin formation. In addition, miRNAs are essential for the development of astrocytes, and inhibition of miRNA genesis completely blocks astrogliogenesis in the spinal cord.

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