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microRNA-mediated regulation of innate immune response in rheumatic diseases

Authors
  • Luo, Xiaobing1, 2
  • Ranade, Koustubh2
  • Talker, Ronel3
  • Jallal, Bahija2
  • Shen, Nan1
  • Yao, Yihong2
  • 1 Shanghai JiaoTong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Joint Molecular Rheumatology Laboratory of Institute of Health Sciences and Shanghai Renji Hospital, 145 Shan Dong Middle Road, Shanghai, 200001, China , Shanghai (China)
  • 2 MedImmune, One MedImmune Way, Gaithersburg, MD, 20878, USA , Gaithersburg (United States)
  • 3 University of Cambridge, School of Pre-Clinical Medicine, Downing College, Cambridge, CB2 1DQ, UK , Cambridge (United Kingdom)
Type
Published Article
Journal
Arthritis Research & Therapy
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Apr 09, 2013
Volume
15
Issue
2
Identifiers
DOI: 10.1186/ar4194
Source
Springer Nature
Keywords
License
Yellow

Abstract

miRNAs have been shown to play essential regulatory roles in the innate immune system. They function at multiple levels to shape the innate immune response and maintain homeostasis by direct suppression of the expression of their target proteins, preferentially crucial signaling components and transcription factors. Studies in humans and in disease models have revealed that dysregulation of several miRNAs such as miR-146a and miR-155 in rheumatic diseases leads to aberrant production of and/or signaling by inflammatory cytokines and, thus, critically contributes to disease pathogenesis. In addition, the recent description of the role of certain extracellular miRNAs as innate immune agonist to induce inflammatory response would have direct relevance to rheumatic diseases.

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