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MicroRNA-544 promotes colorectal cancer progression by targeting forkhead box O1.

Authors
  • Yao, Guo-Dong1, 2, 3, 4
  • Zhang, Ya-Feng4
  • Chen, Peng4
  • Ren, Xiu-Bao1, 2, 3
  • 1 Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, P.R. China. , (China)
  • 2 Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, P.R. China. , (China)
  • 3 Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, P.R. China. , (China)
  • 4 Department of Surgery, Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia Autonomous Region 010050, P.R. China. , (China)
Type
Published Article
Journal
Oncology Letters
Publisher
Spandidos Publications
Publication Date
Jan 01, 2018
Volume
15
Issue
1
Pages
991–997
Identifiers
DOI: 10.3892/ol.2017.7381
PMID: 29422969
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Dysregulation of microRNAs has been confirmed to serve an important role in cancer development and progression. However, the role of microRNA (miR)-544 in colorectal cancer progression remains unknown. In the present study, it was observed that the expression level of miR-544 was increased in breast cancer cell lines and tissues using the quantitative polymerase chain reaction. Overexpression of miR-544 promoted cell proliferation and invasion in colorectal cancer, whereas inhibition of miR-544 suppressed colorectal cancer progression as determined using MTT, colony formation and Transwell assays. Furthermore, forkhead box O1 (FOXO1) was a direct target of miR-544. FOXO1 mediated miR-544-regulated colorectal cancer progression and cell cycle distribution. In conclusion, the results of the present study revealed that miR-544 serves an important role in promoting human colorectal cancer cell progression.

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