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The microRNA-424/503 cluster: A master regulator of tumorigenesis and tumor progression with paradoxical roles in cancer.

Authors
  • Wu, Ye1
  • Wang, Wei2
  • Yang, An-Gang3
  • Zhang, Rui4
  • 1 State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, 710032, Xi' an, China. , (China)
  • 2 State Key Laboratory of Cancer Biology, Department of Immunology, The Fourth Military Medical University, 710032, Xi' an, China. , (China)
  • 3 State Key Laboratory of Cancer Biology, Department of Immunology, The Fourth Military Medical University, 710032, Xi' an, China. Electronic address: [email protected] , (China)
  • 4 State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, 710032, Xi' an, China; State Key Laboratory of Cancer Biology, Department of Immunology, The Fourth Military Medical University, 710032, Xi' an, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Cancer letters
Publication Date
Aug 23, 2020
Volume
494
Pages
58–72
Identifiers
DOI: 10.1016/j.canlet.2020.08.027
PMID: 32846190
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

MicroRNAs (miRNAs) are a group of non-coding RNAs that play a crucial role in post-transcriptional gene regulation and act as indispensable mediators in several critical biological processes, including tumorigenesis, tissue homeostasis, and regeneration. MiR-424 and miR-503 are intragenic miRNAs that are clustered on human chromosome Xq26.3. Previous studies have reported that both miRNAs are dysregulated and play crucial but paradoxical roles in tumor initiation and progression, involving different target genes and molecular pathways. Moreover, these two miRNAs are concomitantly expressed in several cancer cells, indicating a coordinating function as a cluster. In this review, the roles and regulatory mechanisms of miR-424, miR-503, and miR-424/503 cluster are summarized in different types of cancers. Copyright © 2020 Elsevier B.V. All rights reserved.

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